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Found 69 from Drexel University College of Medicine
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.210nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50006990(CHEMBL299499 | N-Adamantan-1-yl-N'-(4-iodo-phenyl)...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50240232(CHEMBL4080735)
Affinity DataKi:  3nMAssay Description:Displacement of [125I]-IPAG from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50240230(CHEMBL4092687)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50240229(CHEMBL4084182)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50240234(CHEMBL4065001)
Affinity DataKi:  45nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50240231(CHEMBL4098778)
Affinity DataKi:  46nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50074933(2-biphenyl-4-yl-propionic acid | CHEMBL317434 | al...)
Affinity DataKi:  130nMAssay Description:Binding affinity of compound towards prostaglandin G/H synthase 1 was evaluatedMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50074922((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity of compound towards prostaglandin G/H synthase 1 was evaluatedMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50240233(CHEMBL4102152)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I]-IPAG from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50074922((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...)
Affinity DataIC50:  12nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50074933(2-biphenyl-4-yl-propionic acid | CHEMBL317434 | al...)
Affinity DataIC50:  32nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50240231(CHEMBL4098778)
Affinity DataIC50:  109nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50139251(2-(3-Bromo-4-isobutyl-phenyl)-propionic acid | CHE...)
Affinity DataIC50:  110nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50240229(CHEMBL4084182)
Affinity DataIC50:  216nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50240230(CHEMBL4092687)
Affinity DataIC50:  417nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50240229(CHEMBL4084182)
Affinity DataIC50:  430nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells by Qpatch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50006990(CHEMBL299499 | N-Adamantan-1-yl-N'-(4-iodo-phenyl)...)
Affinity DataIC50:  491nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50009859((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Affinity DataIC50:  1.06E+3nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50006990(CHEMBL299499 | N-Adamantan-1-yl-N'-(4-iodo-phenyl)...)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells by Qpatch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRecQ-like DNA helicase BLM(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50440531(CHEMBL2426168)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of BLM helicase (unknown origin) binding to DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50139244(2-Biphenyl-4-yl-N,N-dimethyl-propionamide | CHEMBL...)
Affinity DataIC50:  4.80E+3nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50440531(CHEMBL2426168)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of WRN helicase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50139248(2-(2-Fluoro-biphenyl-4-yl)-propionamide | CHEMBL35...)
Affinity DataIC50:  8.30E+3nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDouble-strand break repair protein MRE11(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50044627(Mirin)
Affinity DataIC50:  1.20E+4nMAssay Description:In vitro inhibition of purified recombinant Mre11 exonuclease activity (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50139250(2-Biphenyl-4-yl-N-methyl-propionamide | CHEMBL1619...)
Affinity DataIC50:  1.95E+4nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50044626(CHEMBL1374426)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of WRN helicase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50218812((3R,4R)-3,4-bis(1,3-benzodioxol-5-ylmethyl)dihydro...)
Affinity DataIC50:  2.06E+4nMAssay Description:Inhibition of GAT-1 (unknown origin) expressed in african green monkey COS7 cells using [3H]-GABA as substrate after 10 mins by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50139247(2-(2-Fluoro-biphenyl-4-yl)-N-methyl-propionamide |...)
Affinity DataIC50:  2.40E+4nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50139242(2-Biphenyl-4-yl-propionic acid methyl ester | CHEM...)
Affinity DataIC50:  2.85E+4nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM48804(3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of human RAD51-mediated DNA branch migration using [32P]-labeled 5'-joint molecules after 8 hrs by branch migration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM48804(3-(phenylmethyl)-2-[(E)-2-(3-pyridinyl)ethenyl]-4-...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of human RAD51-mediated DNA strand exchange at using pBSK (+) gapped and linear dsDNA substrates by joint molecule formation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRecQ-like DNA helicase BLM(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50440531(CHEMBL2426168)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of BLM helicase (unknown origin) assessed as branch migration activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50139243(2-(4-Isobutyl-3-nitro-phenyl)-propionic acid | CHE...)
Affinity DataIC50:  5.90E+4nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStructural capsid protein(Human immunodeficiency virus 1)
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50490577(CHEMBL497058)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of HIV1 capsidMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50139249(2-Biphenyl-4-yl-propionamide | CHEMBL162029)
Affinity DataIC50:  6.45E+4nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDouble-strand break repair protein MRE11(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50044627(Mirin)
Affinity DataIC50:  6.60E+4nMAssay Description:Inhibition of Mre11 exonuclease activity (unknown origin) in cell free extractsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50218812((3R,4R)-3,4-bis(1,3-benzodioxol-5-ylmethyl)dihydro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of EAAT2 (unknown origin) expressed in african green monkey COS7 cells using [3H]-glutamic acid as substrate after 10 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50139246(2-(2-Fluoro-biphenyl-4-yl)-propionic acid methyl e...)
Affinity DataIC50:  2.10E+5nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50139245(2-(2-Fluoro-biphenyl-4-yl)-N,N-dimethyl-propionami...)
Affinity DataIC50:  2.15E+5nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50218812((3R,4R)-3,4-bis(1,3-benzodioxol-5-ylmethyl)dihydro...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of GAT-3 (unknown origin) expressed in african green monkey COS7 cells using [3H]-GABA as substrate after 10 mins by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 1(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50218812((3R,4R)-3,4-bis(1,3-benzodioxol-5-ylmethyl)dihydro...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of EAAT1 (unknown origin) expressed in african green monkey COS7 cells using [3H]-glutamic acid as substrate after 10 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50218812((3R,4R)-3,4-bis(1,3-benzodioxol-5-ylmethyl)dihydro...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of EAAT3 (unknown origin) expressed in african green monkey COS7 cells using [3H]-glutamic acid as substrate after 10 mins by scintillatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50218812((3R,4R)-3,4-bis(1,3-benzodioxol-5-ylmethyl)dihydro...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of GlyT1 (unknown origin) expressed in MDCK cells using [3H]-glycine as substrate after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell cycle checkpoint protein RAD1(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM39120(3-chloranyl-1-(3,4-dichlorophenyl)-4-morpholin-4-y...)
Affinity DataEC50:  5.00E+3nMAssay Description:Inhibition of RAD1 (unknown origin) binding to ssDNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
Drexel University College Of Medicine

Curated by ChEMBL
LigandPNGBDBM50595740(CHEMBL5202745)
Affinity DataEC50:  0.300nMAssay Description:Activation of human EAAT2 expressed in rat Astrocytes assessed as glutamate uptake by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAndrogen receptor(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50407398(ABIRATERONE ACETATE | CB7630 | Zytiga)
Affinity DataEC50:  1.71E+4nMAssay Description:Antagonist activity at full length human androgen receptor expressed in mammalian expression system measured after 22 to 24 hrs by luciferase reporte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50425732(ENZALUTAMIDE | US10053433, FC 4.129 | US10806720, ...)
Affinity DataEC50:  420nMAssay Description:Antagonist activity at full length human androgen receptor expressed in mammalian expression system measured after 22 to 24 hrs by luciferase reporte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAndrogen receptor(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50240230(CHEMBL4092687)
Affinity DataEC50:  2.81E+4nMAssay Description:Antagonist activity at full length human androgen receptor expressed in mammalian expression system measured after 22 to 24 hrs by luciferase reporte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Drexel University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50240229(CHEMBL4084182)
Affinity DataEC50:  1.27E+4nMAssay Description:Antagonist activity at full length human androgen receptor expressed in mammalian expression system measured after 22 to 24 hrs by luciferase reporte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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