TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine
Curated by ChEMBL
Drexel University College of Medicine
Curated by ChEMBL
Affinity DataKi: 0.210nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine
Curated by ChEMBL
Drexel University College of Medicine
Curated by ChEMBL
Affinity DataKi: 2.70nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine
Curated by ChEMBL
Drexel University College of Medicine
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Displacement of [125I]-IPAG from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine
Curated by ChEMBL
Drexel University College of Medicine
Curated by ChEMBL
Affinity DataKi: 13nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine
Curated by ChEMBL
Drexel University College of Medicine
Curated by ChEMBL
Affinity DataKi: 38nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine
Curated by ChEMBL
Drexel University College of Medicine
Curated by ChEMBL
Affinity DataKi: 45nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine
Curated by ChEMBL
Drexel University College of Medicine
Curated by ChEMBL
Affinity DataKi: 46nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataKi: 130nMAssay Description:Binding affinity of compound towards prostaglandin G/H synthase 1 was evaluatedMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataKi: 1.00E+3nMAssay Description:Binding affinity of compound towards prostaglandin G/H synthase 1 was evaluatedMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Drexel University College of Medicine
Curated by ChEMBL
Drexel University College of Medicine
Curated by ChEMBL
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I]-IPAG from sigma1 in human MDA-MB-468 cell membranesMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Drexel University College of Medicine
Curated by ChEMBL
Drexel University College of Medicine
Curated by ChEMBL
Affinity DataIC50: 109nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Drexel University College of Medicine
Curated by ChEMBL
Drexel University College of Medicine
Curated by ChEMBL
Affinity DataIC50: 216nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Drexel University College of Medicine
Curated by ChEMBL
Drexel University College of Medicine
Curated by ChEMBL
Affinity DataIC50: 417nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Drexel University College of Medicine
Curated by ChEMBL
Drexel University College of Medicine
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells by Qpatch clamp methodMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Drexel University College of Medicine
Curated by ChEMBL
Drexel University College of Medicine
Curated by ChEMBL
Affinity DataIC50: 491nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.06E+3nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Drexel University College of Medicine
Curated by ChEMBL
Drexel University College of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human ERG expressed in CHOK1 cells by Qpatch clamp methodMore data for this Ligand-Target Pair
TargetRecQ-like DNA helicase BLM(Homo sapiens (Human))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of BLM helicase (unknown origin) binding to DNAMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 4.80E+3nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Homo sapiens (Human))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of WRN helicase (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 8.30E+3nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetDouble-strand break repair protein MRE11(Homo sapiens (Human))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.20E+4nMAssay Description:In vitro inhibition of purified recombinant Mre11 exonuclease activity (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.95E+4nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Homo sapiens (Human))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of WRN helicase (unknown origin)More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Homo sapiens (Human))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.06E+4nMAssay Description:Inhibition of GAT-1 (unknown origin) expressed in african green monkey COS7 cells using [3H]-GABA as substrate after 10 mins by scintillation countin...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.40E+4nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.85E+4nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of human RAD51-mediated DNA branch migration using [32P]-labeled 5'-joint molecules after 8 hrs by branch migration assayMore data for this Ligand-Target Pair
TargetDNA repair protein RAD51 homolog 1(Homo sapiens (Human))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of human RAD51-mediated DNA strand exchange at using pBSK (+) gapped and linear dsDNA substrates by joint molecule formation assayMore data for this Ligand-Target Pair
TargetRecQ-like DNA helicase BLM(Homo sapiens (Human))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of BLM helicase (unknown origin) assessed as branch migration activityMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 5.90E+4nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetStructural capsid protein(Human immunodeficiency virus 1)
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of HIV1 capsidMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 6.45E+4nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetDouble-strand break repair protein MRE11(Homo sapiens (Human))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of Mre11 exonuclease activity (unknown origin) in cell free extractsMore data for this Ligand-Target Pair
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of EAAT2 (unknown origin) expressed in african green monkey COS7 cells using [3H]-glutamic acid as substrate after 10 mins by scintillatio...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.10E+5nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.15E+5nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 3(Homo sapiens (Human))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of GAT-3 (unknown origin) expressed in african green monkey COS7 cells using [3H]-GABA as substrate after 10 mins by scintillation countin...More data for this Ligand-Target Pair
TargetExcitatory amino acid transporter 1(Homo sapiens (Human))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of EAAT1 (unknown origin) expressed in african green monkey COS7 cells using [3H]-glutamic acid as substrate after 10 mins by scintillatio...More data for this Ligand-Target Pair
TargetExcitatory amino acid transporter 3(Homo sapiens (Human))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of EAAT3 (unknown origin) expressed in african green monkey COS7 cells using [3H]-glutamic acid as substrate after 10 mins by scintillatio...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of GlyT1 (unknown origin) expressed in MDCK cells using [3H]-glycine as substrate after 10 mins by scintillation countingMore data for this Ligand-Target Pair
TargetCell cycle checkpoint protein RAD1(Homo sapiens (Human))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataEC50: 5.00E+3nMAssay Description:Inhibition of RAD1 (unknown origin) binding to ssDNAMore data for this Ligand-Target Pair
TargetExcitatory amino acid transporter 2(Homo sapiens (Human))
Drexel University College Of Medicine
Curated by ChEMBL
Drexel University College Of Medicine
Curated by ChEMBL
Affinity DataEC50: 0.300nMAssay Description:Activation of human EAAT2 expressed in rat Astrocytes assessed as glutamate uptake by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 1.71E+4nMAssay Description:Antagonist activity at full length human androgen receptor expressed in mammalian expression system measured after 22 to 24 hrs by luciferase reporte...More data for this Ligand-Target Pair
Affinity DataEC50: 420nMAssay Description:Antagonist activity at full length human androgen receptor expressed in mammalian expression system measured after 22 to 24 hrs by luciferase reporte...More data for this Ligand-Target Pair
Affinity DataEC50: 2.81E+4nMAssay Description:Antagonist activity at full length human androgen receptor expressed in mammalian expression system measured after 22 to 24 hrs by luciferase reporte...More data for this Ligand-Target Pair
Affinity DataEC50: 1.27E+4nMAssay Description:Antagonist activity at full length human androgen receptor expressed in mammalian expression system measured after 22 to 24 hrs by luciferase reporte...More data for this Ligand-Target Pair